Journal Article

Nitric Oxide Scavenging Activity, Total Phenolic and Flavonoid Content of Persea Americana Fruit Peel Mediated Silver, Gold and Alloy Nanoparticles

Oke M.A., Adebayo E.A. & Aina D.A.

Vol 2, Issue 1, Article number: 8 (Aug, 2021)
https://doi.org/10.48187/stnanomat.2021.2.006

Highlight

  • This study established the potential of Persea americana for the synthesis and characterization of nanoparticles.
  • It also established the potential of synthesized PA-AgNPs, PA-AuNPs and PA-Ag-AuNPs as nitric oxide scavengers.
  • The antioxidant activity of the PA-AgNPs, PA-AuNPs and PA-Ag-AuNPs using phenolic and flavonoid contents was established in this study.

Graphical Abstract

Abstract

Green synthesis of nanoparticles which involve using biological material such as plants extracts has attracted a great attention of recent. In the current study, Persea americana (PA) fruit peel were used to synthesis silver nanoparticles (PA-AgNPs), gold nanoparticles (PA-AuNPs) and alloy bimetallic nanoparticles (PA-Ag-AuNPs) and their antioxidant activity using Nitric oxide scavenging assay alongside with total phenolic content (TPC) and flavonoid content (TFC) were evaluated. The study showed that, the nitric oxide scavenging activity, total phenolic and total flavonoid contents of the synthesized nanoparticles increased in a dose dependent manner as compared to the standard. PAAg-AuNPs have the highest nitric scavenging power of 68.5%, followed by PA-AuNPs (66%) and the least value of 48.9% obtained in PA-AgNPs at concentration of 100 µg/ml. PA-Ag-AuNPs and PA-AuNPs showed same value of total phenolic content (250.19 µg GAE/g), while PA-AgNPs gave 249.43 µg GAE/g as least value at concentration at 100 µg/ml. The highest total flavonoid content of 129.73 µg g-1 QE was displayed by PA-AgNPs with the least value of 82.10 µg g-1 QE obtained in PA-Ag-AuNPs. The results obtained confirmed P. americana fruit peel as a potential biomaterial for nanoparticle synthesis which can be exploited for its antioxidant activity. In summary, these fascinating bioactivities exhibited by the synthesized nanoparticles in this study showed their prospect in therapeutic biomedical applications.
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